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Vardenafil was originally marketed by 3 companies working together; Schering-Plough, GlaxoSmithKline and Bayer Pharmaceuticals, under the brand name, Levitra. It is prescribed to men who suffer from problems achieving or keeping an erection, a condition known widely as Erectile Dysfunction (ED). This condition is thought to have affected 40% of men aged 40 years and above, and 70% of men aged 70 and above.

With more than 300 million men predicted to be affected by this condition globally, there are more and more treatment options appearing to help with erection problems. Where there is a demand, opportunistic businesses will appear to fill it. Due to the convenience of online shopping, many people have abandoned the long-established way of buying products and services through retail. This has applied to all sectors of business.

Online pharmacies have begun to make a large presence within the eCommerce world. By large, they sell generic medications which are just as good as the brand-name medications people can find in high street pharmacies. The only difference between brand-name and generic medications is the price, as generic versions are available at a fraction of the cost.

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What is Vardenafil?

Vardenafil is used to treat Erectile Dysfunction (ED) in men and falls within the class of medications known as phosphodiesterase (PDE) inhibitors. Vardenafil works by both increasing blood flow to the genital area during sexual stimulation and also reducing the action of the natural chemical which makes erections go away. This causes a long-lasting erection.

Vardenafil cannot cure erectile dysfunction or increase a mans desire for sexual intercourse but can help maintain an erection long enough for sexual intercourse. Vardenafil is usually only available through prescription only and comes in film-coated tablets in sizes of 5mg, 10mg and 20mg. Patients with underlying medical conditions related to blood pressure, or heart problems should be cautious about taking Vardenafil.

Vardenafil is just approved for men currently. Although studies have found it may work for women, more research into this area is needed. Vardenafil should be stored safely away in the original packet it came in, tightly closed. It should also be stored at room temperature away from heat, moisture and light. For safety reasons, it should be kept high up, away from and out of the reach of children or pets.

What Is Vardenafil Used For?

Erectile Dysfunction (ED), otherwise known as impotence, is a category of sexual dysfunction where the penis cannot initiate or maintain an erection during sexual activities. Erectile dysfunction is the most common sexual problem in the world, affecting many men globally. When a man fails to perform, it is known to cause psychological problems due to the way it can induce depression and create a strain in sexual relationships.

The causes of this condition are vast, most of which are physical problems attributed to other, underlying health conditions. These conditions include; diabetes, cardiovascular disease and neurological problems following prostatectomy, side effects of other medications or hypogonadism. Around 10% of cases are caused by psychological problems, like; anxiety or stress. This is identifiable by patients in these cases responding to a placebo.

Most of the time, primary treatments for this condition start with simple lifestyle changes which address the underlying causes. Following that, if these fail to work, a doctor will then prescribe ED medications such as Vardenafil hydrochloride tablets. These are to be taken orally. These medications are vasodilators, which open up blood vessels and promote the flow of blood to certain areas of the body, in this case, the genitals.

How Does Vardenafil Work?

Vardenafil works by encouraging more blood to flow to the penis. The medication does this by relaxing the blood vessels in the muscle tissue found in the penis. When a man becomes sexually aroused, nitric oxide is released from endothelial cells and nerve terminals in the penis. When this happens an enzyme named guanylate cyclase is activated. This results in the synthesis of cGMP (also known as cyclic guanosine monophosphate) in the smooth muscle tissue of the penis.

This results in vasodilation, which is when blood vessels widen when relaxed. These types of medications were created by accident. It happened during the development of medications intended to relax blood vessels and promote blood flow in patients with problems relating to high blood pressure. In the human trials of the medication they were developing, chemists were surprised to find out it also relaxed the blood vessels in the penis and promote an erection.

Through vasodilation, it has been shown to help other conditions such as pulmonary hypertension. This is a serious medical condition which is related to high blood pressure in arteries and blood vessels between the heart and lungs. The medication has also been reported to help mountaineers when dealing with altitude sickness through the same mechanism of action.

How Long Does Vardenafil Take to Work?

The effects of the medication do not begin on their own. Sexual stimulation is necessary for the patient to gain an erection. Vardenafil takes around 60 minutes to work, depending on age and if they have eaten a large meal before taking their tablet. Vardenafil should only be taken once a day, one hour before a patient has sex, to give time for the patient to metabolize and allow for better results of the medications effects.

This once-a-day dose is usually for the 10mg tablet form. The maximum dose recommended for Vardenafil is 20mg per day, which should only be taken in one, 24-hour period, if a doctor recommends it first. If a patient exceeds this amount in a 24-hour period, they will be more at risk of experiencing unpleasant side effects.

Vardenafil tablets should never be chewed or crushed and should always be swallowed whole with a large glass of water. If tablets are broken, it may interfere with the way the medication works and put users at risk of adverse effects. Vardenafil can be taken with or without food, although a large, high-fat meal may slightly slow the effects.

How Long Does Vardenafil Last?

Vardenafil has a listed duration of action of 4-6 hours from one hour after oral administration. There are some things which can delay the effects of Vardenafil. If patients eat a large meal before taking their dosage, it may slow down the way the body digests the medication. This can also happen if a meal is rich in fats or salts, as they are not good for the liver.

Despite otherwise being a very good source of fibre, vitamin C and other nutrients, grapefruit and grapefruit juice can interact with many different medications, including this one. Grapefruit is a fruit which inhibits certain enzymes in the liver which are responsible for the metabolism of some medications. This will prevent the metabolism of the medication from being effective.

As this prevents the metabolism of a medication, it will remain present in the blood, and the effects can be felt for longer. This can be dangerous as the effects of a medication can interfere with daily life. Vardenafil lowers blood pressure, which is something that may be good for some people, but not for everyone. For maximum effectiveness of this medication, patients should maintain a healthy diet throughout treatment.

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What Vardenafil Dosage Should I take?

Vardenafil is more potent than other similar medications, like sildenafil, by nearly 10 times. Because of this, the dosage amounts are reduced to 5mg, 10mg and 20mg. The recommended dosage of this medication is 10mg per day. The maximum dosage is 20mg, but this should only be taken within a 24-hour period if a doctor has suggested it first.

A reduced dosage may be suggested for those who are new to Vardenafil. There are rare cases where patients can exhibit sensitivity to certain medications, and doctors may want to trial a low dosage first, to be safe. With adults who are 65 years of age or older, a reduced dosage of 5mg would be prescribed and increased further in treatment, if necessary. Again the maximum dosage would be 20mg per 24-hour period.

When taking any dosage of Vardenafil it is important to make sure the medication is a legitimate product. Follow the treatment plans discussed and always take Vardenafil as advised by a medical professional. Store the medication out of sight and reach of children and animals. When receiving medications, always check the expiry date before use.

Vardenafil Side Effects

As with every medication, there are side effects to acknowledge before a patient begins treatment using it. Some side effects are more serious than others, however, if any of the side effects of this medication are prolonged or persist longer than wanted, contact a doctor for help or advice. Common side effects of Vardenafil are;

  • Flushing (increased blood flow to the face)
  • Congested or runny nose
  • Dizziness
  • Indigestion

Some of the more serious side effects of Vardenafil may include;

  • Irregular heartbeat
  • Breathlessness
  • Prolonged erection
  • Back pain
  • Muscular stiffness
  • Vertigo, ringing ears

To be on the safe side, patients should always fully disclose their histories of allergic reactions. This can help a doctor minimize the risks of them occurring again. Allergic reactions may include symptoms such as;

  • Swelling (Especially in the face area)
  • Trouble breathing
  • Severe dizziness
  • Rashes, pealing or itching

These are very rare, but in the event of them happening, emergency services should be contacted. To minimize the risks of experiencing these, follow the instructions of a doctor at all times when taking medications. For a full list of side effects, please refer to the patient information leaflet.

How to Avoid Vardenafil Side Effects

The best way a patient can avoid the side effects of Vardenafil is to make sure they are living a healthy lifestyle through treatment and following the treatment plan as closely as possible. By eating a balanced diet, drinking enough water and getting enough exercise the body can metabolize this medication without any problems. Drinking 2 litres of water a day, at least, is recommended normally. Whilst on medication, this should be taken more seriously, as it helps to flush toxins from the system.

Whenever going through treatments, patients should always maintain a healthy diet and try their best to get enough sleep at night. These, along with exercise can ensure that bodily functions are working at their best. Three modestly sized meals a day, along with exercise which is not too strenuous should be enough. As mentioned earlier, grapefruit (or grapefruit juice) should be avoided.

When taking Vardenafil, one unit of alcohol, maximum, is recommended. As Vardenafil lowers blood pressure, alcohol can further this effect. Patients who take Vardenafil with alcohol are more at risk of side effects which can cause faintness or dizziness. This can be dangerous and should be avoided. If a patient wishes to drink more than one unit of alcohol, they should discuss this with their doctor first.

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Dr Sophie Laurent
Reviewed by:

Dr Sophie Laurent

Meet Dr Sophie Laurent, a medical professional who is passionate about helping patients overcome sexual dysfunction and who also has a profound love of literature.

Checked on : 30 October 2022
Next check : 30 October 2023

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